In accordance with eco-industrial park construction principles,this research makes use of game theory to analyze a variety of interests' Game pattern between similar enterprises,different enterprises and enterprises-governments respectively.combined with the practice of Guangzhou Development industrial park,it discussed the solutions and made corresponding advice.To similar enterprises,the (pollute) constitutes a Nash equilibrium,and more inclined to uncooperative.Different categories (heterogeneous) enterprises tended to be more cooperative in the game pattern,will choose (cooperate).And the environment will not be polluted.Only companies choose the polluting strategy,between the government and enterprises Game relationship does exist.This is a dynamic game of uncertainties.This game is different from purely economic activities because the punishment may be the consequence of temporary maintaining a normal level of profitability and unpolluted public environment quality.