Correlation analysis of body mass index and clinicopathological characteristics of papillary thyroid carcinoma

SHANG Zhaoyang, LI Guoquan, ZHANG Lingyu, QIU Xinguang

Journal of Jinan University Natural Science & Medicine Edition ›› 2022, Vol. 43 ›› Issue (1) : 53-61.

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Journal of Jinan University Natural Science & Medicine Edition ›› 2022, Vol. 43 ›› Issue (1) : 53-61. DOI: 10.11778/j.jdxb.2022.01.006

Correlation analysis of body mass index and clinicopathological characteristics of papillary thyroid carcinoma

  • SHANG Zhaoyang, LI Guoquan, ZHANG Lingyu, QIU Xinguang*
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Abstract

Objective: This study was designed to explore the correlation between body mass index (BMI) and clinicopathological characteristics of papillary thyroid carcinoma (PTC). Methods: The clinical data of patients who underwent surgical treatment in the department of thyroid surgery of the First Affiliated Hospital of Zhengzhou University from January 1, 2018 to December 31, 2018 were retrospectively analyzed. They were assigned to the underweight group,the normal weight group,the overweight group and the obese group according to BMI. Univariate and multivariate analyses were used to compare the clinicopathological characteristics of PTC patients with different BMI groups. The relationship between BMI and cervical lymph node metastasis was analyzed by ROC curve. Results: In the univariate analysis, there was a statistically significant difference in gender, central lymph node metastasis, cervical lateral lymph node metastasis, capsule invasion, BRAF gene mutation, multifocal, TNM stage and tumor maximum diameter among different BMI groups (all P<0.05). Multivariate analysis showed that age >55 years was a protective factor for cervical lymph node metastasis, while high BMI and maximum tumor diameter >10 mm were risk factors for cervical lymph node metastasis (all P<0.05). The ROC curve results suggested a higher risk of cervical lymph node metastasis in men with a BMI of >24.19 kg·m-2 and women with a BMI of >24.09 kg·m-2. Conclusion: This study showed that low body weight, overweight, and obesity were all associated with some adverse clinicopathological features of PTC. There were high risk of cervical lymph node metastasis in male patients with BMI>24.19 kg·m-2 and female patients with BMI>24.09 kg·m-2, who needed more detailed preoperative examination to evaluate the tumor status.

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body mass index / papillary thyroid carcinoma / obesity / clinicopathological features

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SHANG Zhaoyang, LI Guoquan, ZHANG Lingyu, QIU Xinguang. Correlation analysis of body mass index and clinicopathological characteristics of papillary thyroid carcinoma. Journal of Jinan University Natural Science & Medicine Edition. 2022, 43(1): 53-61 https://doi.org/10.11778/j.jdxb.2022.01.006

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