After Zhang Qian's travels in Western Regions, the official relationship between the Han Empire and the Parthian Empire was established, and then the Silk Road traversed the Parthian Empire and continued to extent to the Mediterranean World. In terms of the historical development of transportation in the Western Section of the Silk Road, the Parthian Age is an extremely important stage. Although in the pre-Parthian era, the traffic in the western part of the Silk Roads had already taken shaped, the instability of the political situation in the western section had greatly hindered the further development of the traffic pattern. With the rise of the Parthian Empire and its effective governance on the traffic, the western part of the Silk Roads achieved an unprecedented development under the guarantee of the unified order of the Parthian Empire and formed a new traffic pattern across the middle main line, together with the north and south branch lines. It is helpful to study the relationship between Parthian Empire and the Silk Road by investigating the traffic routes in the western section of the Silk Road during the Parthian period.