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Figure/Table detail
Effect and mechanism of Modified Danggui Buxuetang on AMPK and PGC-1
α
in diabetic kidney disease rats
DING Xin, GU Yue, WANG Yifan, SHEN Yuhang, ZHANG Yuxiang, GUO Dengzhou
Journal of Jinan University Natural Science & Medicine Edition
, 2023, 44(
2
): 147-156. DOI:
10.11778/j.jdxb.20220367
Figure 1
The sketch map of pathogenesis of DKD
Other figure/table from this article
Figure 2
Effect of MDBT on 24 h-UTP of DKD rats
1)Compared with CON group,
P
<0.01; 2) Compared with MOD group,
P
<0.01
Figure 3
Effect of MDBT on serum MnSOD and MDA of DKD rats
A: Change of MnSOD activity; B: Change of MDA level. 1)Compared with CON group,
P
<0.01; 2)Compared with MOD group,
P
<0.05; 3)Compared with MOD group,
P
<0.01
Figure 4
Effect of MDBT on pathological changes of renal tissue of DKD rats (HE, ×400)
The black triangle: separation of the renal tubules from the renal sacs; The black arrow: the disappearance of the brush border of the renal tubules; The blue triangle: mesangial matrix in the glomeruli increased; The blue arrows: uniform thickening of the basement membrane within the glomeruli
Figure 5
Effect of MDBT on pathological changes of renal tissue of DKD rats (PAS, ×400)
The black triangle: glycogen deposition in the glomeruli; The black arrow: the apparent disappearance of the brush edge of the renal tubules; The blue triangle: mesangial matrix in the glomeruli increased; The blue arrows: uniform thickening of the glomerular basement membrane
Figure 6
Effect of MDBT on pathological changes of renal tissue of DKD rats (MASSON, ×400)
The black arrow: fibroplasia in the renal tubule interstitial; The yellow arrows: hyperplasia of glomerular basement membrane fibers
Figure 7
Effect of MDBT on the expression of
p
-AMPK、PGC-1
α
protein and localization expression in renal tissues of DKD rats (IHC, ×400)
A: Change of
p
-AMPK protein expression; B:PGC-1
α
protein expression changes; C: Quantization of changes in localization expression of
p
-AMPK and PGC-1
α
. 1)Compared with CON group,
P
<0.01; 2)Compared with MOD group,
P
<0.05; 3)Compared with MOD group,
P
<0.01
Figure 8
The effect of MDBT on the electrophoresis and expression of
p
-AMPK、PGC-1
α
protein in renal tissue of rats (Western blot)
A: Bands of
p
-AMPK and PGC-1
α
protein electrophoresis; B: Quantization of changes of
p
-AMPK and PGC-1
α
protein expression. 1)Compared with CON group,
P
<0.01; 2)Compared with MOD group,
P
<0.05; 3)Compared with MOD group,
P
<0.01
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