Journal of Jinan University Natural Science & Medicine Edition

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Effect and mechanism of Modified Danggui Buxuetang on AMPK and PGC-1α in diabetic kidney disease rats

DING Xin, GU Yue, WANG Yifan, SHEN Yuhang, ZHANG Yuxiang, GUO Dengzhou

Journal of Jinan University Natural Science & Medicine Edition, 2023, 44(2): 147-156. DOI: 10.11778/j.jdxb.20220367

Figure 3 Effect of MDBT on serum MnSOD and MDA of DKD rats A: Change of MnSOD activity; B: Change of MDA level. 1)Compared with CON group, P<0.01; 2)Compared with MOD group, P<0.05; 3)Compared with MOD group, P<0.01

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Figure 1 The sketch map of pathogenesis of DKD
Figure 2 Effect of MDBT on 24 h-UTP of DKD rats 1)Compared with CON group, P<0.01; 2) Compared with MOD group, P<0.01
Figure 4 Effect of MDBT on pathological changes of renal tissue of DKD rats (HE, ×400) The black triangle: separation of the renal tubules from the renal sacs; The black arrow: the disappearance of the brush border of the renal tubules; The blue triangle: mesangial matrix in the glomeruli increased; The blue arrows: uniform thickening of the basement membrane within the glomeruli
Figure 5 Effect of MDBT on pathological changes of renal tissue of DKD rats (PAS, ×400) The black triangle: glycogen deposition in the glomeruli; The black arrow: the apparent disappearance of the brush edge of the renal tubules; The blue triangle: mesangial matrix in the glomeruli increased; The blue arrows: uniform thickening of the glomerular basement membrane
Figure 6 Effect of MDBT on pathological changes of renal tissue of DKD rats (MASSON, ×400) The black arrow: fibroplasia in the renal tubule interstitial; The yellow arrows: hyperplasia of glomerular basement membrane fibers
Figure 7 Effect of MDBT on the expression of p-AMPK、PGC-1α protein and localization expression in renal tissues of DKD rats (IHC, ×400) A: Change of p-AMPK protein expression; B:PGC-1α protein expression changes; C: Quantization of changes in localization expression of p-AMPK and PGC-1α. 1)Compared with CON group, P<0.01; 2)Compared with MOD group, P<0.05; 3)Compared with MOD group, P<0.01
Figure 8 The effect of MDBT on the electrophoresis and expression of p-AMPK、PGC-1α protein in renal tissue of rats (Western blot) A: Bands of p-AMPK and PGC-1α protein electrophoresis; B: Quantization of changes of p-AMPK and PGC-1α protein expression. 1)Compared with CON group, P<0.01; 2)Compared with MOD group, P<0.05; 3)Compared with MOD group, P<0.01

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