Journal of Jinan University Natural Science & Medicine Edition

Analysis of oral microbiota composition in maintenance hemodialysis patients

YU Xinyuan, QIU Yufang, DAI Zhida, ZHANG Zhixiang, HU Qiaobin, ZHANG Chunlei, LIU Fanna, LI Jinghua

Journal of Jinan University Natural Science & Medicine Edition, 2025, 46(2): 175-184. DOI: 10.11778/j.jdxb.20240373

组别	n	年龄/岁			性别 (n_男/n_女)		eGFR/ [mL/(min·1.73 m²)]
HC组	16	42.94±5.81			5/11		98.36(92.51,103.73)
MHD组	25	47.44±11.88			15/10		6.83(6.01,7.23)
P值	-	0.115			0.072		<0.001
组别	CPI指数n(%)
组别	0		1	2		3		4	X
HC组	1(6.3)		9(56.3)	2(12.5)		3(18.8)		1(6.3)	0(0.0)
MHD组	0(0.0)		2(8.0)	4(16.0)		9(36.0)		10(40.0)	0(0.0)
P值	<0.001

Table 1 Comparison of clinical data between MHD group and HC group

Other figure/table from this article

Figure 1 Rarefaction curve of oral microbiota in HC group and MHD group
Figure 2 α diversity of oral microbiota in HC group and MHD group (A)Chao1 index;(B)ACE index;(C)Simpson index;(D)Shannon index. *P<0.05
Figure 3 PCoA analysis based on Bray Curtis distance
Figure 4 Community composition of oral microbiota in HC group and MHD group (A)Stacked bar plot at phylum level;(B)Significance analysis between groups at phylum level;(C)Significance analysis between groups at genus level. *P<0.05,**P<0.01,***P<0.001
Figure 5 LEfSe analysis of oral microbiota in HC group and MHD group (A)Histogram of LDA value distribution of oral microbiota (The length of the bar chart represents the impact size of the differential species); (B)Cladogram of oral microbiota (The circles radiating from the center represent the taxonomic ranks from phylum to species, with the nodes representing a classification at that level. Different colors indicate different groups, with non-significant species colored yellow, and significant species colored according to their respective groups).
Figure 6 Prediction of oral microbiota function in HC group and MHD group *P<0.05,**P<0.01
Figure 7 Spearman correlation analysis between oral microbiota and clinical parameters *P<0.05,**P<0.01,***P<0.001